The Science of Sound:
Breaking the Cycle of Stress: How Your Mind Rewires Your Immune System
About the episode
2025’s Nobel Prize in Physiology/Medicine puts regulatory T cells (Tregs) and the FOXP3 gene center stage—and in this episode, Christian Fowler joins host Aaron Fournier to connect that discovery to everyday tools that lower stress and inflammation. We break down how IL-10 from Tregs crosses the blood–brain barrier to reduce neuroinflammation, why chronic stress down-regulates FOXP3 (and Tregs), and how mindset, vagal tone, sleep, sunlight, movement, and targeted sound (like 528 Hz) can help flip you from fight-or-flight into rest-and-digest. We also discuss studies showing Treg expansion reduces anxiety-like behavior, brief/acute stress boosts dopamine and learning, and chronic stress suppresses immune tolerance—plus practical “wins” (make your bed, humming, Mindful Intentions) that build resilience daily.
Show Notes
00:00 Introduction
02:00 Discovery of T-Reg Cells and the FOXP3 Gene
04:00 How IL-10 Lowers Neuroinflammation
06:00 Chronic Stress and the Nervous System
08:00 Identifying Your “Saber-Toothed Tiger” Stressors
10:00 The Vicious Cycle of Stress and Gene Expression
12:00 T-Reg Transfer Study Reduces Anxiety in Mice
14:00 Chronic Stress Suppresses FOXP3 Expression
16:00 Breaking the Cycle: Hope Through Neuroplasticity
18:00 528Hz Music and Hormonal Balance
20:00 Human T-Reg Expansion Study and Inflammation Drop
22:00 Daily Practices to Upregulate Healing Genes
24:00 Recognizing Signs of Chronic Stress
26:00 Reframing the Mind: Positive Focus and Gratitude
28:00 Gender-Specific Stress Responses and Oxytocin
30:00 Acute Stress, Dopamine, and Learning
34:00 Small Wins and Building Resilience
38:00 Mindset, Movement, and Whole-Body Integration
00:00 Introduction
02:00 Discovery of T-Reg Cells and the FOXP3 Gene
04:00 How IL-10 Lowers Neuroinflammation
06:00 Chronic Stress and the Nervous System
08:00 Identifying Your “Saber-Toothed Tiger” Stressors
10:00 The Vicious Cycle of Stress and Gene Expression
12:00 T-Reg Transfer Study Reduces Anxiety in Mice
14:00 Chronic Stress Suppresses FOXP3 Expression
16:00 Breaking the Cycle: Hope Through Neuroplasticity
18:00 528Hz Music and Hormonal Balance
20:00 Human T-Reg Expansion Study and Inflammation Drop
22:00 Daily Practices to Upregulate Healing Genes
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About Aaron
Aaron Fournier, Co-founder and President of Soaak Digital, combines legal expertise with a passion for holistic wellness to drive Soaak’s groundbreaking wellness-tech innovations. His leadership has expanded Soaak Digital, creating transformative sound frequency solutions and securing a key contract with the USAF. Under his guidance, the Soaak app reaches 190 countries, enhancing mental health globally.
About Henry and Laura
Henry Penix, CEO and Co-founder of Soaak Technologies, is a visionary leader dedicated to advancing holistic wellness through cutting-edge technology. Laura Widney, Co-founder and President of Soaak Clinics, is passionate about integrating science and spirituality to support mental, physical, and emotional well-being. Together, they are on a mission to transform lives through innovative wellness solutions.
About Madi
Madison Fournier, Co-Founder and CMO of Soaak Technologies, leads a dynamic marketing team focused on transformative strategies in health tech. Her expertise in digital marketing and market trends has shaped Soaak’s successful campaigns, fostering innovation and driving growth. Madison's leadership has positioned Soaak as a pioneer in health tech marketing.
